Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation

Title: Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation
Creator: Prieto-García, Alicia; Castells, Mariana C.; Hansbro, Philip M.; Stevens, Richard L.
Relation: Immunology and Allergy Clinics of North America Vol. 34, Issue 2, p. 263-281
Publisher Link: http://dx.doi.org/10.1016/j.iac.2014.01.001
Publisher: W.B. Saunders
Resource Type: journal article
Date: 2014
Description: Tetramer-forming tryptase (hTryptase-ß) was recently discovered to have a prominent role in preventing the internal accumulation of life-threatening fibrin deposits and fibrin-platelet clots. The anticoagulant activity of hTryptase-ß is an explanation for the presence of hemorrhagic disorders in some patients with anaphylaxis or mastocytosis. The fragments of hFibrinogen formed by the proteolysis of this prominent protein by hTryptase-ß could be used as biomarkers in the blood and/or urine for the identification and monitoring of patients with mast cell-dependent disorders. Recombinant hTryptase-ß has potential to be used in clinical settings where it is desirable to inhibit blood coagulation.
Subject: mast cell; hTryptase-β; mMCP-6; mMCP-7; fibrinogen; fibrin thrombin-dependent coagulation; anaphylaxis
Identifier: http://hdl.handle.net/1959.13/1304128
Identifier: uon:20803
Identifier: ISSN:0889-8561
Language: eng
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